Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574988 | 0.90 | DYRK1A (0.50) | DYRK1ADYRK1BCYP1B1ALDH1A1CYP3A4 | |
| SCHEMBL8431822 | 0.89 | ALDH1A1 (0.50) | CYP1B1ALDH1A1CYP3A4KDM4EHPGD | |
| SCHEMBL8427304 | 0.89 | DYRK1A (0.52) | DYRK1ADYRK1BCYP1B1ALDH1A1CYP3A4 | |
| SCHEMBL8570785 | 0.87 | HDAC6 (0.56) | CYP1B1ALDH1A1CYP3A4KDM4EHPGD | |
| SCHEMBL8307616 | 0.84 | CYP1A1 (0.58) | DYRK1ADYRK1BCYP1B1KDM4ECYP1A2 | |
| SCHEMBL7379704 | 0.84 | DYRK1A (0.64) | DYRK1ADYRK1BCYP1B1ALDH1A1KDM4E | |
| SCHEMBL10472448 | 0.81 | CYP1A2 (0.63) | CYP1B1ALDH1A1CYP3A4KDM4EHPGD | |
| SCHEMBL10473384 | 0.81 | CYP1B1 (0.72) | CYP1B1ALDH1A1CYP3A4KDM4EHPGD | |
| SCHEMBL8431081 | 0.80 | ALDH1A1 (0.48) | DYRK1ADYRK1BCYP1B1ALDH1A1CYP3A4 | |
| SCHEMBL8429609 | 0.79 | ALDH1A1 (0.53) | CYP1B1ALDH1A1CYP3A4KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803503-B1 | Acids and esters of diosmetin and pharmaceutical compositions containing them | ADIR (FR) | 1999-11-03 | — | — | EP | disclosed |
| US-5792789-A | TREATING HYPERPERMEABILITY AND INFLAMMATION | ADIR ET COMPAGNIE (FR) | 1998-08-11 | — | — | US | disclosed |
| EP-0803503-A1 | Acids and esters of diosmetin and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-10-29 | — | — | EP | disclosed |