Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622526 | 0.88 | ACHE (0.46) | ACHEKDM4EMAPTMETAP1ALDH1A1 | |
| SCHEMBL4624026 | 0.88 | GAA (0.43) | ACHEPDE3BPDE3AALDH1A1GAA | |
| SCHEMBL21061523 | 0.79 | PDE3B (0.48) | PDE3BPDE3AMAPTALDH1A1GAA | |
| SCHEMBL4622406 | 0.78 | SMN1; SMN2 (0.44) | PDE3BPDE3AALDH1A1GAAHTT | |
| SCHEMBL7951579 | 0.74 | EIF2AK2 (0.43) | ACHEPDE3BPDE3AMETAP1ALDH1A1 | |
| SCHEMBL10815402 | 0.74 | KMT2A (0.39) | MAPTALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL10815403 | 0.74 | KMT2A (0.39) | MAPTALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL7834528 | 0.71 | BRD4 (0.56) | KDM4EMAPTALDH1A1CREBBPTSHR | |
| SCHEMBL7818827 | 0.71 | KMT2A (0.43) | MAPTALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL7818824 | 0.71 | KMT2A (0.43) | MAPTALDH1A1HTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971878-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND USE AS AMYLOID-BETA PRODUCTION INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998038156-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND USE AS AMYLOID-BETA PRODUCTION INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-03 | — | — | WO | disclosed |