Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622406 | 0.86 | SMN1; SMN2 (0.44) | EIF2AK2HTR5AGAAALDH1A1HTT | |
| SCHEMBL4624026 | 0.85 | GAA (0.43) | EIF2AK2HTR5AGAAALDH1A1HTT | |
| SCHEMBL4622546 | 0.81 | HTR5A (0.43) | HTR5AALDH1A1CA1CA2ACHE | |
| SCHEMBL153506 | 0.75 | EIF2AK2 (0.74) | EIF2AK2HTR5AGAAALDH1A1SRC | |
| SCHEMBL7380212 | 0.74 | ACHE (0.39) | EIF2AK2GAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21061523 | 0.74 | PDE3B (0.48) | GAAALDH1A1PDE3BPDE3AMAOA | |
| SCHEMBL17057353 | 0.72 | CRBN (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL4622631 | 0.71 | SRC (0.44) | EIF2AK2HTR5AALDH1A1CA2ACHE | |
| SCHEMBL4623068 | 0.71 | OPRK1 (0.46) | HTR5AALDH1A1SRCMETAP1TSHR | |
| SCHEMBL7833042 | 0.71 | PDE3B (0.47) | ALDH1A1CA1CA2ACHESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329389-B1 | HETEROCYCLIC AMINES AND DERIVATIVES, SOMATOSTATIN AND ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-12-11 | — | — | US | disclosed |