Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | MGAM | O43451 | 5/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.42 |
| ▸ | SI | P14410 | 5/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849673 | 0.78 | EGLN3 (0.56) | POLBAPAF1EGLN3MAPTKDM4E | |
| SCHEMBL4227322 | 0.78 | SLC9A1 (0.51) | POLBAPAF1MAPTALDH1A1MAPK1 | |
| SCHEMBL2069140 | 0.75 | HSD17B10 (0.50) | POLBAPAF1EGLN3MAPTKDM4E | |
| SCHEMBL22032189 | 0.75 | SLC9A1 (0.50) | POLBAPAF1MAPTALDH1A1MAPK1 | |
| SCHEMBL1311735 | 0.75 | POLB (0.46) | POLBAPAF1EGLN3MAPTKDM4E | |
| SCHEMBL4865115 | 0.75 | MAPT (0.45) | POLBAPAF1EGLN3MAPTKDM4E | |
| SCHEMBL1312900 | 0.75 | POLB (0.46) | POLBAPAF1EGLN3MAPTKDM4E | |
| SCHEMBL1312663 | 0.75 | POLB (0.46) | POLBAPAF1EGLN3MAPTKDM4E | |
| SCHEMBL9091544 | 0.75 | POLB (0.55) | POLBAPAF1EGLN3MAPTGAA | |
| SCHEMBL9091462 | 0.74 | POLB (0.51) | POLBAPAF1EGLN3GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |