Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.56 |
| ▸ | CYP4Z1 | Q86W10 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP4F8 | P98187 | 1/20 | 0.48 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MGAM | O43451 | 3/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.44 |
| ▸ | SI | P14410 | 3/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22032189 | 0.80 | SLC9A1 (0.50) | CYP4Z1CYP1A2POLBAPAF1SLC9A1 | |
| SCHEMBL1652528 | 0.78 | SLC9A1 (0.53) | CYP4Z1CYP1A2POLBGAAMGAM | |
| SCHEMBL7380423 | 0.78 | POLB (0.43) | EGLN3CYP4Z1CYP1A2POLBAPAF1 | |
| SCHEMBL10321887 | 0.77 | EGLN3 (0.47) | EGLN3CYP4Z1CYP1A2CYP2C8CYP2B6 | |
| SCHEMBL4227322 | 0.76 | SLC9A1 (0.51) | CYP4Z1CYP1A2POLBAPAF1SLC9A1 | |
| SCHEMBL9091462 | 0.76 | POLB (0.51) | EGLN3CYP4Z1CYP1A2CYP2C8CYP2B6 | |
| SCHEMBL25613143 | 0.75 | SLC9A1 (0.55) | CYP4Z1CYP1A2POLBGAAMGAM | |
| SCHEMBL31066856 | 0.75 | SLC9A1 (0.55) | CYP4Z1CYP1A2POLBGAAMGAM | |
| SCHEMBL13401722 | 0.75 | APAF1 (0.54) | EGLN3CYP4Z1CYP1A2CYP2C8CYP2B6 | |
| SCHEMBL513851 | 0.75 | POLB (0.50) | EGLN3CYP4Z1CYP1A2CYP2C8CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115741-B2 | 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds | ALEXION PHARMACEUTICALS, INC. | 2006-10-03 | — | — | US | disclosed |
| US-20030153556-A1 | Piperazine and homopiperazine compounds | MILLENNIUM PHARMACEUTICALS, INC. | 2003-08-14 | — | — | US | disclosed |
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153556-A1 | Piperazine and homopiperazine compounds | HAMP, MPL, F2 | EGLN3 34/4885CYP4Z1 95/4885CYP1A2 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.