Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | GLI1 | P08151 | 1/20 | 0.47 |
| ▸ | GLI2 | P10070 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | EPOR | P19235 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30371750 | 0.89 | PTGS1 (0.64) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL7381199 | 0.88 | PTGS1 (0.54) | PTGS1MEN1CYP2D6KMT2ACTSK | |
| SCHEMBL5110019 | 0.84 | PTGS1 (0.67) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL1716112 | 0.82 | CYP2C19 (0.53) | PTGS1CYP2D6CTSKCTSSCTSL | |
| SCHEMBL4310706 | 0.81 | CTSK (0.67) | CTSKCTSSCTSL | |
| SCHEMBL4039064 | 0.81 | CTSK (0.67) | CTSKCTSSCTSL | |
| SCHEMBL4309572 | 0.81 | CTSK (0.67) | CTSKCTSSCTSL | |
| SCHEMBL6925413 | 0.81 | PTGS1 (0.62) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL8813325 | 0.81 | PTGS1 (0.62) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| Fenoprofen SCHEMBL8754928 | 0.81 | PTGS1 (1.00) | PTGS1MEN1CYP2D6KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019046-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020049316-A1 | Protease inhibitors | HALBERT STACIE MARIE (US) | 2002-04-25 | — | — | US | disclosed |
| CN-1261276-A | Protease inhibitors | SMITHKLINE BEECHAM CORP (US) | 2000-07-26 | — | — | CN | disclosed |
| EP-1019046-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998048799-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
| US-4245108-A | BY CONDENSING A MERCAPTAN, A HALOFORM AND A PHENOXYBENZALDEHYDE OR A THIOPHENECARBOXALDEHYDE | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1981-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049316-A1 | Protease inhibitors | CTSK, CTSZ, CTSG | PTGS1 167/4885MEN1 1159/4885CYP2D6 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.