Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | C1S | P09871 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20863187 | 0.78 | ALDH1A1 (0.34) | ALDH1A1MAPK1TAAR1IDO1AGXT | |
| SCHEMBL28374403 | 0.78 | ALDH1A1 (0.34) | ALDH1A1MAPK1TAAR1IDO1AGXT | |
| SCHEMBL3667921 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPK1TAAR1IDO1AGXT | |
| SCHEMBL13400303 | 0.76 | CYP1A2 (0.41) | ALDH1A1MAPK1TAAR1C1SPARP1 | |
| SCHEMBL246078 | 0.73 | CYP3A4 (0.35) | ALDH1A1TDP1 | |
| SCHEMBL20048776 | 0.72 | ALDH1A1 (0.39) | ALDH1A1MAPK1TAAR1IDO1AGXT | |
| SCHEMBL513922 | 0.72 | ALDH1A1 (0.44) | ALDH1A1MAPK1TAAR1IDO1AGXT | |
| SCHEMBL1710651 | 0.72 | MEN1 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL7329519 | 0.72 | ACHE (0.42) | ALDH1A1MAPK1TAAR1IDO1AGXT | |
| SCHEMBL1710338 | 0.71 | L3MBTL1 (0.33) | ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |