SCHEMBL7380717

SCHEMBL7380717

Cc1cc(C[CH]Cc2cccnc2)cc(C)c1N

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
CHRNB2 P17787 3/20 0.41
CHRNA4 P43681 3/20 0.41
CYP2A6 P11509 1/20 0.40
HTT P42858 1/20 0.40
TSHR P16473 1/20 0.40
ALDH1A1 P00352 1/20 0.40
KDM4E B2RXH2 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7383588 0.82 MEN1 (0.40) CHRNA7MEN1KMT2ACHRNB2CHRNA4
SCHEMBL7382585 0.81 MEN1 (0.47) CHRNA7MEN1KMT2ACHRNB2CHRNA4
SCHEMBL7379200 0.80 CYP11B1 (0.40) CHRNB2CHRNA4CYP2A6HTTTSHR
SCHEMBL7377822 0.78 HTT (0.40) CHRNA7MEN1KMT2ACHRNB2CHRNA4
SCHEMBL7384069 0.78 CHRNB2 (0.43) CHRNA7CHRNB2CHRNA4CYP2A6HTT
SCHEMBL8726941 0.76 LTA4H (0.52) CHRNA7CHRNB2CHRNA4CYP2A6CYP1A2
SCHEMBL7381665 0.76 MAPT (0.47) CHRNA7MEN1KMT2ACHRNB2CHRNA4
SCHEMBL7384351 0.76 CYP1A2 (0.43) CHRNA7MEN1KMT2ACHRNB2CHRNA4
SCHEMBL7384248 0.75 HTR1A (0.45) CHRNB2CHRNA4TSHRALDH1A1KDM4E
SCHEMBL31220151 0.75 CHRNA7 (0.42) CHRNA7MEN1KMT2ACHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1165500-A1 AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE Du Pont Pharmaceuticals Company (US) 2002-01-02 EP disclosed
WO-2000059874-A1 NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE DU PONT PHARMACEUTICALS COMPANY (US) 2000-10-12 WO disclosed