Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.56 |
| ▸ | FEN1 | P39748 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135637 | 0.85 | MAPT (0.56) | ERCC5FEN1MAPTMEN1KMT2A | |
| SCHEMBL30440405 | 0.83 | MAPT (0.48) | ERCC5FEN1TSHRMAPTMEN1 | |
| SCHEMBL9080934 | 0.83 | MAPT (0.48) | ERCC5FEN1TSHRMAPTMEN1 | |
| SCHEMBL2089796 | 0.83 | MAPT (0.49) | ERCC5FEN1TSHRMAPTMEN1 | |
| SCHEMBL16253911 | 0.83 | MAPT (0.48) | ERCC5FEN1TSHRMAPTMEN1 | |
| SCHEMBL2071218 | 0.79 | FEN1 (0.52) | FEN1MAPTMEN1KMT2ATAS1R3 | |
| SCHEMBL395494 | 0.78 | MAPT (0.56) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL3767429 | 0.78 | ALDH1A1 (0.59) | ERCC5FEN1TSHRMAPTMEN1 | |
| SCHEMBL3142115 | 0.77 | ERCC5 (0.62) | ERCC5FEN1TSHRMEN1KMT2A | |
| SCHEMBL24410395 | 0.76 | MAPT (0.41) | ERCC5FEN1TSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488519-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT | PF MEDICAMENT (FR) | 2015-06-10 | — | — | EP | disclosed |
| US-8889711-B2 | Pyrazolopyridine derivatives as anticancer agent | PIERRE FABRE MEDICAMENT (FR) | 2014-11-18 | — | — | US | disclosed |
| EP-0459830-A1 | Pharmacologically active CNS compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |
| EP-0044119-B1 | PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE | STAMICARBON B.V. (NL) | 1985-05-29 | — | — | EP | disclosed |
| US-4435552-A | COORDINATION CATALYST CONTAINING HALOACYL COMPOUND | STAMICARBON B.V. (NL) | 1984-03-06 | — | — | US | disclosed |
| EP-0044119-A2 | Process for the preparation of copolymers of ethylene with at least one other 1-alkene | STAMICARBON B.V. (NL) | 1982-01-20 | — | — | EP | disclosed |