Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 4/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11382094 | 0.85 | PRCP (0.37) | PRCPDPP7TLR2NOS2NOS3 | |
| SCHEMBL11558601 | 0.82 | PRCP (0.34) | PRCPDPP7TLR2NOS2CYP1A2 | |
| SCHEMBL11450387 | 0.81 | HTR2C (0.35) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL9362980 | 0.80 | PRCP (0.44) | PRCPDPP7TLR2NOS2NOS3 | |
| SCHEMBL30265157 | 0.80 | PRCP (0.44) | PRCPDPP7TLR2NOS2NOS3 | |
| SCHEMBL7380818 | 0.80 | PRCP (0.33) | PRCPDPP7TLR2CYP1A2CYP3A4 | |
| SCHEMBL7378973 | 0.80 | NOS2 (0.35) | PRCPDPP7TLR2NOS2NOS3 | |
| SCHEMBL3662902 | 0.79 | NOS2 (0.37) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL542283 | 0.79 | NOS2 (0.39) | PRCPDPP7NOS2NOS3NOS1 | |
| SCHEMBL3489282 | 0.78 | NOS2 (0.35) | PRCPDPP7TLR2NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |