Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.53 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675588 | 0.80 | ASH1L (0.74) | GSK3BCDK5DYRK1AASH1LALDH1A1 | |
| SCHEMBL13302236 | 0.79 | HTR1A (0.55) | ASH1LALDH1A1ATMMEN1KMT2A | |
| SCHEMBL29933114 | 0.74 | KDM1A (0.53) | MAPTKDM4ECHEK2HSD17B10KDM4B | |
| SCHEMBL7038517 | 0.74 | KDM5C (0.69) | MAPTKDM4EPIM1HSD17B10MKNK1 | |
| SCHEMBL31127913 | 0.73 | CLK1 (0.59) | GSK3BCDK5DYRK1ACLK1CDK5R1 | |
| SCHEMBL11258541 | 0.73 | CLK1 (0.59) | GSK3BCDK5DYRK1ACLK1CDK5R1 | |
| SCHEMBL1758494 | 0.73 | KDM4C (0.51) | GSK3BCDK5DYRK1AMAPTKDM4E | |
| SCHEMBL2335933 | 0.73 | KDM4C (0.51) | ALDH1A1MAPTKDM4ECLK4HSD17B10 | |
| SCHEMBL20030496 | 0.72 | DYRK1A (0.72) | GSK3BCDK5DYRK1ACLK1CDK5R1 | |
| SCHEMBL7710271 | 0.72 | MAPT (0.66) | GSK3BCDK5DYRK1ACLK1CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |