Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388466 | 0.90 | REN (0.49) | RENCTSD | |
| SCHEMBL7389362 | 0.89 | REN (0.57) | RENCTSD | |
| SCHEMBL7389545 | 0.89 | REN (0.51) | RENCTSD | |
| SCHEMBL7395091 | 0.87 | REN (0.45) | RENCTSD | |
| SCHEMBL7387941 | 0.86 | MMP2 (0.49) | RENMMP3MMP1MMP2 | |
| SCHEMBL7280475 | 0.86 | REN (0.46) | RENCTSD | |
| SCHEMBL7277983 | 0.85 | REN (0.44) | RENCTSD | |
| SCHEMBL7392745 | 0.84 | REN (0.49) | RENCTSD | |
| SCHEMBL7392758 | 0.84 | REN (0.49) | RENCTSD | |
| SCHEMBL7393080 | 0.84 | REN (0.49) | RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589445-B1 | Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1997-01-15 | — | — | EP | claimed |
| WO-1994007846-A1 | RENIN INHIBITING N-(2-AMINO-2-OXOETHYL)BUTANEDIAMIDE DERIVATIVES | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-04-14 | — | — | WO | claimed |