Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.49 |
| ▸ | MMP3 | P08254 | 8/20 | 0.49 |
| ▸ | MMP1 | P03956 | 6/20 | 0.49 |
| ▸ | REN | P00797 | 8/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392096 | 0.95 | MMP3 (0.44) | MMP2MMP3MMP1RENEPHX2 | |
| SCHEMBL7384225 | 0.89 | REN (0.52) | MMP2MMP3MMP1REN | |
| SCHEMBL7391215 | 0.88 | BCHE (0.40) | MMP2MMP3MMP1REN | |
| SCHEMBL7394306 | 0.88 | BCHE (0.40) | MMP2MMP3MMP1REN | |
| SCHEMBL7383323 | 0.86 | REN (0.49) | MMP2MMP3MMP1REN | |
| SCHEMBL7390005 | 0.86 | REN (0.38) | MMP2MMP3MMP1REN | |
| SCHEMBL7394314 | 0.86 | PSEN1 (0.40) | MMP2MMP3MMP1REN | |
| SCHEMBL7389599 | 0.86 | PSEN1 (0.40) | MMP2MMP3MMP1REN | |
| SCHEMBL7390565 | 0.85 | GAA (0.42) | REN | |
| SCHEMBL7394858 | 0.85 | REN (0.46) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589445-B1 | Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1997-01-15 | — | — | EP | claimed |