Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 7/20 | 0.61 |
| ▸ | MMP13 | P45452 | 4/20 | 0.60 |
| ▸ | MMP9 | P14780 | 6/20 | 0.59 |
| ▸ | MMP2 | P08253 | 5/20 | 0.59 |
| ▸ | MMP3 | P08254 | 4/20 | 0.59 |
| ▸ | MMP1 | P03956 | 2/20 | 0.59 |
| ▸ | MMP7 | P09237 | 2/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.54 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.54 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383553 | 1.00 | ADAMTS4 (0.61) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL7381912 | 0.91 | ADAMTS4 (0.58) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL7381915 | 0.91 | ADAMTS4 (0.58) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL6390804 | 0.85 | ADAMTS4 (0.64) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL6390801 | 0.85 | ADAMTS4 (0.64) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL6381667 | 0.78 | NPC1 (0.56) | MMP13MMP9MMP2MMP3MMP1 | |
| SCHEMBL7376000 | 0.78 | MMP9 (0.74) | MMP13MMP9MMP2MMP3MMP1 | |
| SCHEMBL7375998 | 0.78 | MMP9 (0.74) | MMP13MMP9MMP2MMP3MMP1 | |
| SCHEMBL5839717 | 0.78 | MMP9 (0.92) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL2161549 | 0.78 | MMP9 (0.92) | ADAMTS4MMP13MMP9MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934267-B1 | ALPHA-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | UPJOHN CO (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-0934267-A1 | $g(a)-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5804593-A | FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. | PHARMACIA & UPJOHN COMPANY (US) | 1998-09-08 | — | — | US | disclosed |
| WO-1998017645-A1 | α-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-30 | — | — | WO | disclosed |