SCHEMBL7375998

SCHEMBL7375998

COc1ccc(S(=O)(=O)N[C@@H](C(=O)NO)C(C)C)cc1

nearest known ligand 0.74

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 11/20 0.74
MMP2 P08253 9/20 0.74
MMP1 P03956 9/20 0.74
MMP13 P45452 8/20 0.74
MMP3 P08254 6/20 0.74
MMP7 P09237 6/20 0.74
MMP8 P22894 1/20 0.69
ADAM17 P78536 1/20 0.66
SLC1A3 P43003 1/20 0.59
SLC1A2 P43004 1/20 0.59
SLC1A1 P43005 1/20 0.59
RAB9A P51151 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7376000 1.00 MMP9 (0.74) MMP9MMP2MMP1MMP13MMP3
SCHEMBL7417565 0.85 MMP9 (0.64) MMP9MMP2MMP1MMP13MMP3
SCHEMBL7347163 0.85 MMP9 (0.72) MMP9MMP2MMP1MMP13MMP3
SCHEMBL2161452 0.85 MMP9 (0.92) MMP9MMP2MMP1MMP13MMP3
SCHEMBL2161549 0.85 MMP9 (0.92) MMP9MMP2MMP1MMP13MMP3
SCHEMBL6723663 0.85 MMP9 (0.72) MMP9MMP2MMP1MMP13MMP3
SCHEMBL5839717 0.85 MMP9 (0.92) MMP9MMP2MMP1MMP13MMP3
SCHEMBL6723666 0.85 MMP9 (0.72) MMP9MMP2MMP1MMP13MMP3
SCHEMBL7419690 0.84 MMP2 (0.91) MMP9MMP2MMP1MMP13MMP3
SCHEMBL7420442 0.83 MMP1 (0.69) MMP9MMP2MMP1MMP13MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934267-B1 ALPHA-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS UPJOHN CO (US) 2002-01-30 EP claimed
US-5804593-A FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. PHARMACIA & UPJOHN COMPANY (US) 1998-09-08 US claimed
EP-0934267-B1 ALPHA-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS UPJOHN CO (US) 2002-01-30 EP disclosed
US-6218389-B1 FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES THE PROCTER & GAMBLE CO. 2001-04-17 US disclosed
EP-1009737-A2 SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2000-06-21 EP disclosed
EP-0934267-A1 $g(a)-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-08-11 EP disclosed
WO-1999006340-A2 SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 1999-02-11 WO disclosed
US-5804593-A FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. PHARMACIA & UPJOHN COMPANY (US) 1998-09-08 US disclosed
WO-1998017645-A1 α-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-30 WO disclosed