Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999890 | 0.89 | L3MBTL1 (0.50) | POLBKMT2AHTTLMNATSHR | |
| SCHEMBL1343383 | 0.82 | KMT2A (0.61) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL12569137 | 0.81 | TSHR (0.68) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL5743015 | 0.77 | KMT2A (0.56) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL9003051 | 0.75 | KMT2A (0.68) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL5104062 | 0.75 | POLB (0.63) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL9003054 | 0.75 | KMT2A (0.68) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL5104059 | 0.74 | POLB (0.62) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL27783476 | 0.70 | POLB (0.42) | POLBKMT2AALDH1A1MAPTCYP3A4 | |
| SCHEMBL6626488 | 0.70 | POLB (0.57) | POLBKMT2AALDH1A1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641779-A1 | Novel 1-amidinopiperdines and 4-amidinomorpholines as aggregation inhibitions | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |