Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364821 | 0.87 | LMNA (0.44) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL6765848 | 0.83 | PTGS2 (0.51) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL9428037 | 0.81 | PTGS2 (0.52) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL11443812 | 0.81 | PTGS2 (0.52) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL11434977 | 0.81 | PTGS2 (0.52) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL7721146 | 0.81 | PTGS2 (0.52) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL9428564 | 0.81 | PTGS2 (0.52) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL9560125 | 0.81 | PTGS2 (0.52) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL9428247 | 0.81 | HDAC1 (0.46) | LMNAMEN1KMT2ATHRBBLM | |
| SCHEMBL10285192 | 0.81 | LMNA (0.41) | LMNAMEN1KMT2ATHRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314887-A | Cardiovascular disorders | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-05-24 | — | — | US | disclosed |
| US-5166148-A | Treatment of congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| WO-1992000741-A1 | 2-AMINO-1,4-DIHYDROPYRIDINE DERIVATIVES WITH CALCIUM AGONIST AND ALPHA1-ANTAGONIST ACTIVITY | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-23 | — | — | WO | disclosed |