Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
| ▸ | ITGAL | P20701 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385062 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BMAPTTP53LMNA | |
| SCHEMBL29421743 | 0.82 | APLNR (0.47) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6301729 | 0.81 | SCN9A (0.60) | MTNR1AMTNR1BMAPTSCN9AHTR2A | |
| SCHEMBL30663629 | 0.81 | SCN9A (0.60) | MTNR1AMTNR1BMAPTSCN9AHTR2A | |
| SCHEMBL21384322 | 0.81 | SCN9A (0.60) | MTNR1AMTNR1BMAPTSCN9AHTR2A | |
| SCHEMBL19392083 | 0.76 | KMT2A (0.64) | MAPTTP53MEN1KMT2A | |
| SCHEMBL16645246 | 0.76 | MTNR1A (0.58) | MTNR1AMTNR1BMAPTSCN9AHTR2A | |
| SCHEMBL17938401 | 0.76 | MTNR1A (0.58) | MTNR1AMTNR1BMAPTSCN9AHTR2A | |
| SCHEMBL8490235 | 0.76 | KMT2A (0.64) | MAPTTP53MEN1KMT2A | |
| SCHEMBL27403391 | 0.76 | KMT2A (0.64) | MAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010077-A | Tranquilizers | A/S FERROSAN (DK) | 1991-04-23 | — | — | US | disclosed |
| EP-0030254-B1 | BETA-CARBOLIN-3-CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR THERAPEUTICAL USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-10-31 | — | — | EP | disclosed |
| US-4371536-A | TRANQUILIZERS | A/S FERROSAN (DK) | 1983-02-01 | — | — | US | disclosed |
| EP-0030254-A1 | Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-06-17 | — | — | EP | disclosed |