Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376294 | 0.89 | MAPT (0.49) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL28604399 | 0.78 | KDM4E (0.56) | EGFRKMT2AKDM4ETP53ALDH1A1 | |
| SCHEMBL30034874 | 0.78 | MAPT (0.55) | LMNAMAPTMETAP2KMT2AKDM4E | |
| SCHEMBL28582077 | 0.78 | MAPT (0.55) | LMNAMAPTMETAP2KMT2AKDM4E | |
| SCHEMBL29809422 | 0.75 | METAP2 (0.49) | LMNAMAPTMETAP2KMT2AKDM4E | |
| SCHEMBL6185728 | 0.75 | METAP2 (0.49) | LMNAMAPTMETAP2KMT2AKDM4E | |
| SCHEMBL28585100 | 0.75 | POLB (0.50) | LMNAMAPTGAAKMT2AKDM4E | |
| SCHEMBL28580373 | 0.75 | PMM2 (0.49) | LMNAGAAKMT2AKDM4EALDH1A1 | |
| SCHEMBL2593323 | 0.74 | KDM4E (0.47) | LMNAMAPTMETAP2KMT2AKDM4E | |
| SCHEMBL29431541 | 0.74 | KDM4E (0.47) | LMNAMAPTMETAP2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998038168-A1 | ISOQUINOLINONE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-03 | — | — | WO | claimed |