Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385125 | 0.89 | PDE4A (0.48) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28604399 | 0.78 | KDM4E (0.56) | SMN1; SMN2ALDH1A1KDM4EKMT2APOLB | |
| SCHEMBL28582077 | 0.78 | MAPT (0.55) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL30034874 | 0.78 | MAPT (0.55) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL10975563 | 0.75 | RAB9A (0.55) | MAPTSMN1; SMN2LMNANPSR1KMT2A | |
| SCHEMBL2593323 | 0.74 | KDM4E (0.47) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL29431541 | 0.74 | KDM4E (0.47) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL28592556 | 0.74 | METAP2 (0.49) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29809422 | 0.72 | METAP2 (0.49) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL6185728 | 0.72 | METAP2 (0.49) | MAPTSMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998038168-A1 | ISOQUINOLINONE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-03 | — | — | WO | disclosed |