Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 7/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388092 | 1.00 | MPO (0.36) | MPOMEN1KMT2AMAPTHCRTR2 | |
| SCHEMBL9012834 | 1.00 | MPO (0.36) | MPOMEN1KMT2AMAPTHCRTR2 | |
| SCHEMBL18258131 | 0.70 | SMN1; SMN2 (0.35) | MEN1KMT2AMAPTHCRTR2CNR2 | |
| SCHEMBL7387257 | 0.69 | MPO (0.37) | MPOMEN1KMT2AMAPTHCRTR2 | |
| SCHEMBL7395232 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL7385347 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL6419539 | 0.68 | CNR2 (0.36) | MEN1KMT2AMAPTCNR2CNR1 | |
| SCHEMBL7391678 | 0.67 | SLC9A1 (0.42) | — | |
| SCHEMBL7392631 | 0.67 | SLC9A1 (0.42) | — | |
| SCHEMBL18247382 | 0.66 | CNR2 (0.39) | MEN1KMT2AHCRTR2CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589476-A | TREATMENT OF NAUSEA, VOMITING AND GASTROINTESTINAL DISORDERS | SYNTHELABO (FR) | 1996-12-31 | — | — | US | disclosed |
| EP-0646583-A1 | Derivatives of Imidezol-4-yl piperidine, their preparation and use in therapy | SYNTHELABO (FR) | 1995-04-05 | — | — | EP | disclosed |