Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959370 | 0.86 | KMT2A (0.56) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL8702816 | 0.85 | KMT2A (0.62) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL11109034 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL11109036 | 0.84 | KMT2A (0.56) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL7278316 | 0.81 | EGFR (0.65) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL984736 | 0.81 | EGFR (0.65) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL30443220 | 0.81 | EGFR (0.65) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL29414698 | 0.79 | EGFR (0.66) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL6671401 | 0.79 | EGFR (0.66) | KMT2AALDH1A1LMNAL3MBTL1THRB | |
| SCHEMBL14397448 | 0.79 | ALDH1A1 (0.67) | KMT2AALDH1A1LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540956-B1 | Process for the manufacture of substituted maleimides | HOFFMANN LA ROCHE (CH) | 1997-09-03 | — | — | EP | disclosed |
| US-5399712-A | Protein kinase C inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5192770-A | Antiemetic, anxiolytic, cognition activator | SYNTEX (U.S.A.) INC. (US) | 1993-03-09 | — | — | US | disclosed |
| EP-0490263-A1 | Alpha-oxoacetamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |