Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27668932 | 0.85 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL11507064 | 0.82 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL3631214 | 0.81 | MAPT (0.60) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL7973779 | 0.81 | CHRM2 (0.58) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL738515 | 0.81 | ALDH1A1 (0.48) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL1420874 | 0.80 | ALDH1A1 (0.44) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL10805147 | 0.79 | MAPT (0.58) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL29566643 | 0.79 | MAPT (0.60) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL308233 | 0.79 | MAPT (0.60) | MAPTALDH1A1L3MBTL1MAPK1MEN1 | |
| SCHEMBL7745470 | 0.77 | ALDH1A1 (0.66) | MAPTALDH1A1L3MBTL1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118063438-A | MDM2/MDMX double-target inhibitor compound, prodrug, pharmaceutical composition, preparation method and application thereof | 北京华益健康药物研究中心 | 2024-05-24 | — | — | CN | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |