Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 4/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381210 | 0.92 | NPC1 (0.51) | NPC1LMNAMAPK1MAPTPKM | |
| SCHEMBL7381276 | 0.89 | GAA (0.42) | NPC1CYP19A1CYP17A1MAPTKMT2A | |
| SCHEMBL7381326 | 0.85 | MEN1 (0.44) | HTTLMNAMAPK1CYP19A1CYP17A1 | |
| SCHEMBL7379863 | 0.85 | MEN1 (0.44) | HTTLMNAMAPK1CYP19A1CYP17A1 | |
| SCHEMBL7384136 | 0.85 | MEN1 (0.44) | HTTLMNAMAPK1CYP19A1CYP17A1 | |
| SCHEMBL7387268 | 0.83 | GPBAR1 (0.39) | CYP19A1CYP17A1ALDH1A1MEN1KMT2A | |
| SCHEMBL7377871 | 0.83 | PTGS1 (0.40) | LMNACYP19A1CYP17A1 | |
| SCHEMBL7387023 | 0.79 | KCNQ2 (0.45) | TDP1KDM4E | |
| SCHEMBL7385158 | 0.77 | HSD17B10 (0.43) | HTTLMNAMAPK1MAPTPKM | |
| SCHEMBL7468058 | 0.77 | LMNA (0.37) | HTTLMNAHPGDMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281617-A | Enzyme inhibitor | CORTECH, INC. (US) | 1994-01-25 | — | — | US | claimed |
| US-5281617-A | Enzyme inhibitor | CORTECH, INC. (US) | 1994-01-25 | — | — | US | disclosed |