Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389428 | 0.92 | THRB (0.45) | THRBMAPTLMNASIGMAR1ITGB3 | |
| SCHEMBL7389681 | 0.92 | THRB (0.46) | THRBMAPTLMNASIGMAR1TP53 | |
| SCHEMBL7389136 | 0.89 | SIGMAR1 (0.46) | THRBMAPTLMNASIGMAR1 | |
| SCHEMBL7389109 | 0.89 | THRB (0.51) | THRBMAPTLMNASIGMAR1MEN1 | |
| SCHEMBL7388647 | 0.88 | MAPT (0.48) | THRBMAPTLMNASIGMAR1TP53 | |
| SCHEMBL7386967 | 0.87 | MAPT (0.44) | THRBMAPTLMNASIGMAR1MEN1 | |
| SCHEMBL7383868 | 0.87 | THRB (0.44) | THRBMAPTLMNASIGMAR1TP53 | |
| SCHEMBL7389977 | 0.86 | THRB (0.46) | THRBMAPTLMNASIGMAR1 | |
| SCHEMBL7387950 | 0.86 | THRB (0.45) | THRBSIGMAR1ITGB3ITGA2B | |
| SCHEMBL7381271 | 0.85 | SIGMAR1 (0.46) | THRBMAPTLMNASIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |