Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LSS | P48449 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381271 | 0.93 | SIGMAR1 (0.46) | SIGMAR1THRBMAPTLMNAF10 | |
| SCHEMBL7383868 | 0.93 | THRB (0.44) | SIGMAR1THRBMAPTLMNAF10 | |
| SCHEMBL7389681 | 0.92 | THRB (0.46) | SIGMAR1THRBMAPTLMNAF10 | |
| SCHEMBL7384895 | 0.92 | THRB (0.44) | SIGMAR1THRBMAPTLMNAF10 | |
| SCHEMBL7388548 | 0.92 | MAPT (0.45) | SIGMAR1THRBMAPTLMNAGRM5 | |
| SCHEMBL7386967 | 0.91 | MAPT (0.44) | SIGMAR1THRBMAPTLMNAF10 | |
| SCHEMBL7388713 | 0.91 | THRB (0.46) | SIGMAR1THRBMAPTLMNAF10 | |
| SCHEMBL7388647 | 0.90 | MAPT (0.48) | SIGMAR1THRBMAPTLMNAGRM5 | |
| SCHEMBL7380241 | 0.90 | THRB (0.46) | THRBMAPTLMNAGRM2POLB | |
| SCHEMBL7386639 | 0.90 | POLB (0.53) | SIGMAR1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |