SCHEMBL7388677

SCHEMBL7388677

NC(=O)[C](CCN1CCCCC1)c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.67
KMT2A Q03164 7/20 0.67
GFER P55789 1/20 0.65
POLB P06746 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.51
HSP90AA1 P07900 1/20 0.51
LMNA P02545 1/20 0.50
EGFR P00533 2/20 0.48
MAPT P10636 2/20 0.48
LTA4H P09960 1/20 0.47
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7214356 0.98 ALDH1A1 (0.64) ALDH1A1KMT2AGFERPOLBL3MBTL1
SCHEMBL7385730 0.86 ALDH1A1 (0.49) ALDH1A1KMT2AGFERPOLBL3MBTL1
SCHEMBL7385779 0.85 ALDH1A1 (0.68) ALDH1A1KMT2AHSP90AA1LMNAEGFR
SCHEMBL5356971 0.80 ALDH1A1 (1.00) ALDH1A1KMT2AGFERPOLBL3MBTL1
SCHEMBL10107784 0.80 ALDH1A1 (1.00) ALDH1A1KMT2AGFERPOLBL3MBTL1
Hydrochloric Acid SCHEMBL10675086 0.79 ALDH1A1 (1.00) ALDH1A1KMT2AGFERPOLBLMNA
Hydrochloric Acid SCHEMBL29354698 0.79 ALDH1A1 (1.00) ALDH1A1KMT2AGFERPOLBLMNA
SCHEMBL10507206 0.78 ALDH1A1 (0.96) ALDH1A1KMT2AGFEREGFRMAPT
Hydrochloric Acid SCHEMBL10670221 0.77 ALDH1A1 (0.97) ALDH1A1KMT2AGFERPOLBLMNA
SCHEMBL2725965 0.75 KMT2A (0.90) ALDH1A1KMT2AGFEREGFRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0691961-A1 SUBSTITUTED CAPROLACTAMS AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF HIV DISEASE THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-17 EP claimed
EP-0686151-A1 SUBSTITUTED CYCLIC CARBONYLS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-12-13 EP claimed
WO-1994022840-A1 SUBSTITUTED CAPROLACTAMS AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF HIV DISEASE THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-10-13 WO claimed
US-5559110-A HIV ANTIVIRAL, GOOD SYSTEMIC ABSORPTION ADMINISTERED BY MOUTH THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1996-09-24 US disclosed
EP-0691961-A1 SUBSTITUTED CAPROLACTAMS AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF HIV DISEASE THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-17 EP disclosed
EP-0686151-A1 SUBSTITUTED CYCLIC CARBONYLS AND DERIVATIVES THEREOF USEFUL AS RETROVIRAL PROTEASE INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-12-13 EP disclosed