Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.90 |
| ▸ | GFER | P55789 | 1/20 | 0.87 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 5/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10507206 | 0.96 | ALDH1A1 (0.96) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| Hydrochloric Acid SCHEMBL10670221 | 0.95 | ALDH1A1 (0.97) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| SCHEMBL10107784 | 0.95 | ALDH1A1 (1.00) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| SCHEMBL5356971 | 0.95 | ALDH1A1 (1.00) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| Hydrochloric Acid SCHEMBL29354698 | 0.93 | ALDH1A1 (1.00) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| Hydrochloric Acid SCHEMBL10675086 | 0.93 | ALDH1A1 (1.00) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| SCHEMBL16026463 | 0.92 | KMT2A (0.83) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7934846 | 0.91 | KMT2A (0.83) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| SCHEMBL31093108 | 0.91 | KMT2A (0.74) | KMT2AALDH1A1GFERMAPTSIGMAR1 | |
| SCHEMBL3893679 | 0.86 | KMT2A (0.73) | KMT2AALDH1A1GFERMAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| EP-2635581-B1 | 7-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2635581-B1 | 7-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-25 | — | — | EP | disclosed |
| US-8865715-B2 | Substituted 7-(1,2,3-Triazol-4-yl)-pyrrolo[2,3-b]pyrazines | MERCK PATENT GMBH (DE) | 2014-10-21 | — | — | US | disclosed |
| US-8865715-B2 | Substituted 7-(1,2,3-Triazol-4-yl)-pyrrolo[2,3-b]pyrazines | MERCK PATENT GMBH (DE) | 2014-10-21 | — | — | US | disclosed |
| US-8865715-B2 | Substituted 7-(1,2,3-Triazol-4-yl)-pyrrolo[2,3-b]pyrazines | MERCK PATENT GMBH (DE) | 2014-10-21 | — | — | US | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| EP-2635581-A1 | 7-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-09-11 | — | — | EP | disclosed |
| US-20130217951-A1 | 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217951-A1 | 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217951-A1 | 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-22 | — | — | US | disclosed |
| WO-2012095142-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012095142-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012059171-A1 | 7-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059171-A1 | 7-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217951-A1 | 7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES | PDK1, PDK2, PDK3 | KMT2A 1342/4885ALDH1A1 1183/4885GFER 4831/4885 |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PDK1, PDK2, PDK3 | KMT2A 843/4885ALDH1A1 1206/4885GFER 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.