Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381271 | 0.92 | SIGMAR1 (0.46) | THRBPOLBMAPTLMNATSHR | |
| SCHEMBL7388548 | 0.90 | MAPT (0.45) | THRBPOLBALDH1A1GBA1MAPT | |
| SCHEMBL7389136 | 0.90 | SIGMAR1 (0.46) | THRBPOLBMAPTLMNATSHR | |
| SCHEMBL7388713 | 0.89 | THRB (0.46) | THRBPOLBMAPTLMNATSHR | |
| SCHEMBL7386639 | 0.89 | POLB (0.53) | POLBMAPT | |
| SCHEMBL7384895 | 0.89 | THRB (0.44) | THRBPOLBALDH1A1MAPTLMNA | |
| SCHEMBL7393478 | 0.88 | TNF (0.44) | THRBHSD11B1POLBGBA1MAPT | |
| SCHEMBL7388681 | 0.88 | THRB (0.43) | THRBPOLBMAPTLMNATSHR | |
| SCHEMBL7389040 | 0.86 | THRB (0.42) | THRBPOLBMAPTLMNATSHR | |
| SCHEMBL7592402 | 0.86 | MAPT (0.46) | THRBPOLBMAPTMAOALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |