Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383372 | 0.98 | POLB (0.68) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7382543 | 0.84 | DRD2 (0.56) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7387694 | 0.84 | KDM4E (0.61) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7427501 | 0.84 | ALDH1A1 (0.61) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7387101 | 0.83 | KDM4E (0.60) | POLBKDM4EALDH1A1DRD2DRD1 | |
| SCHEMBL7391693 | 0.83 | DRD2 (0.54) | POLBKDM4EDRD2DRD1DRD5 | |
| SCHEMBL7392098 | 0.83 | KDM4E (0.59) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7388724 | 0.83 | KDM4E (0.59) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL7386166 | 0.79 | DRD2 (0.60) | KDM4EDRD2DRD1DRD5DRD3 | |
| SCHEMBL7390119 | 0.79 | GRIN2B (0.60) | POLBKDM4EALDH1A1DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |