Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.60 |
| ▸ | DRD3 | P35462 | 10/20 | 0.60 |
| ▸ | HTR1A | P08908 | 9/20 | 0.60 |
| ▸ | HTR2A | P28223 | 9/20 | 0.60 |
| ▸ | DRD1 | P21728 | 5/20 | 0.60 |
| ▸ | DRD5 | P21918 | 5/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382543 | 0.95 | DRD2 (0.56) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL7391693 | 0.94 | DRD2 (0.54) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL7390119 | 0.83 | GRIN2B (0.60) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL7387694 | 0.79 | KDM4E (0.61) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL7389692 | 0.79 | POLB (0.69) | DRD2DRD3DRD1DRD5HRH1 | |
| SCHEMBL7427501 | 0.79 | ALDH1A1 (0.61) | KDM4E | |
| SCHEMBL7387101 | 0.78 | KDM4E (0.60) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL7383372 | 0.78 | POLB (0.68) | DRD2DRD3DRD1DRD5HRH1 | |
| SCHEMBL11870245 | 0.78 | DRD2 (0.76) | DRD2DRD3HTR1AHTR2ADRD1 | |
| SCHEMBL11866824 | 0.78 | HTR1A (0.61) | DRD2DRD3HTR1AHTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |