Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666433 | 0.92 | PARP1 (0.60) | POLBDRD2PARP1HTR2BPKM | |
| SCHEMBL14218701 | 0.90 | POLB (0.62) | POLBKDM4EHTR2BPKM | |
| SCHEMBL9870915 | 0.85 | HTR2B (0.56) | POLBDRD2DRD1DRD4DRD5 | |
| SCHEMBL16349536 | 0.84 | PARP1 (0.59) | POLBDRD2KDM4EPARP1HTR2B | |
| SCHEMBL17533943 | 0.84 | PARP1 (0.59) | POLBDRD2KDM4EPARP1HTR2B | |
| SCHEMBL9869376 | 0.82 | HTR2B (0.60) | POLBKDM4EHTR2BPKM | |
| SCHEMBL20001659 | 0.80 | POLB (0.54) | POLBKDM4EPARP1HTR2B | |
| SCHEMBL4148001 | 0.79 | POLB (0.56) | POLBKDM4EHTR2BPKM | |
| SCHEMBL9869744 | 0.79 | PKM (0.56) | POLBKDM4EPARP1HTR2BPKM | |
| SCHEMBL30365989 | 0.79 | PKM (0.56) | POLBKDM4EPARP1HTR2BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |