Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394146 | 0.84 | PANK3 (0.42) | PANK3CYP3A4PTPN11ACHEDRD2 | |
| SCHEMBL7390806 | 0.80 | TRPV1 (0.49) | — | |
| SCHEMBL7393573 | 0.78 | HTR3E (0.51) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL7391400 | 0.76 | PTPN11 (0.53) | PANK3PTPN11 | |
| SCHEMBL20425052 | 0.75 | PANK3 (0.60) | PANK3MEN1KMT2APTPN11ACHE | |
| Fumaric Acid SCHEMBL8699041 | 0.75 | PTPN11 (0.47) | PANK3PTPN11 | |
| SCHEMBL22320681 | 0.75 | ACHE (0.38) | PANK3KDM4EALDH1A1HPGDHSD17B10 | |
| Maleic Acid SCHEMBL8699032 | 0.75 | PTPN11 (0.47) | PANK3PTPN11 | |
| SCHEMBL15260451 | 0.74 | PANK3 (0.46) | PANK3KDM4EPTPN11 | |
| SCHEMBL7384813 | 0.73 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |