SCHEMBL7390959

SCHEMBL7390959

COc1cc(C(NC(C)=O)C2CCN(CCCC(=O)O)CC2)ccc1NC(=O)Nc1ccccc1C

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 9/20 0.44
ITGA4 P13612 9/20 0.44
THRB P10828 1/20 0.43
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
CCR8 P51685 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
GFER P55789 1/20 0.41
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7484795 0.95 ITGB1 (0.45) ITGB1ITGA4THRBKMT2AMEN1
SCHEMBL7392261 0.95 THRB (0.47) ITGB1ITGA4THRBKMT2AMEN1
SCHEMBL7435014 0.93 ITGB1 (0.47) ITGB1ITGA4THRBKMT2ANPSR1
SCHEMBL7388792 0.90 ITGB1 (0.46) ITGB1ITGA4THRBKMT2AMEN1
SCHEMBL7425047 0.90 ITGB1 (0.54) ITGB1ITGA4KMT2AMEN1CCR8
SCHEMBL7382557 0.88 ITGB1 (0.49) ITGB1ITGA4THRBNPSR1
SCHEMBL7426910 0.87 ITGB1 (0.43) ITGB1ITGA4KMT2AMEN1GFER
SCHEMBL7426846 0.87 ITGB1 (0.51) ITGB1ITGA4THRBKMT2AMEN1
SCHEMBL7383245 0.86 ITGB1 (0.49) ITGB1ITGA4KMT2AMEN1
SCHEMBL7429588 0.85 ITGB1 (0.51) ITGB1ITGA4KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999054321-A1 SUBSTITUTED DIAMINES AND THEIR USE AS CELL ADHESION INHIBITORS AVENTIS PHARMA LIMITED (GB) 1999-10-28 WO disclosed