Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 20/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | HTR2A | P28223 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951920 | 0.91 | HTR4 (0.55) | HTR4KCNH2HTR2A | |
| SCHEMBL6953798 | 0.90 | HTR4 (0.53) | HTR4KCNH2HTR2A | |
| Hydrochloric Acid SCHEMBL7393717 | 0.89 | HTR4 (0.65) | HTR4KCNH2HTR2A | |
| Hydrochloric Acid SCHEMBL7394154 | 0.88 | HTR4 (0.66) | HTR4KCNH2HTR2A | |
| SCHEMBL6950149 | 0.86 | HTR4 (0.61) | HTR4KCNH2HTR2A | |
| Hydrochloric Acid SCHEMBL7394609 | 0.86 | HTR4 (0.77) | HTR4KCNH2HTR2A | |
| SCHEMBL7396763 | 0.85 | HTR4 (0.67) | HTR4KCNH2HTR2A | |
| Hydrochloric Acid SCHEMBL7394644 | 0.85 | HTR4 (0.73) | HTR4KCNH2HTR2A | |
| SCHEMBL9054122 | 0.84 | HTR4 (0.58) | HTR4KCNH2HTR2A | |
| SCHEMBL6950902 | 0.83 | HSD17B10 (0.51) | HTR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732333-B1 | Indazolecarboxamides | LILLY CO ELI (US) | 2001-08-01 | — | — | EP | disclosed |
| US-5817676-A | 5-HT4 RECEPTOR ANTAGONISTS, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| US-5798367-A | ANTAGONIZE 5-HYDROXYTRYPTAMINE RECEPTOR IN GASTROINTESTINAL TRACT OR GENITOURINARY TRACT | ELI LILLY AND COMPANY (US) | 1998-08-25 | — | — | US | disclosed |
| US-5654320-A | SEROTONIN RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996033713-A1 | INDAZOLECARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1996-10-31 | — | — | WO | disclosed |
| EP-0732333-A1 | Indazolecarboxamides | ELI LILLY AND COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |