Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.64 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073864 | 0.78 | — | — | |
| SCHEMBL106762 | 0.78 | GABRA1 (1.00) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL27668420 | 0.76 | GABRA1 (0.95) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Methane SCHEMBL10512593 | 0.76 | GABRA1 (0.95) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL5075280 | 0.73 | — | — | |
| SCHEMBL21215035 | 0.73 | APLNR (0.32) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL5073861 | 0.73 | — | — | |
| SCHEMBL717087 | 0.72 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL30871991 | 0.72 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL92503 | 0.72 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074091-B1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | LUNDBECK & CO AS H (DK) | 2015-01-07 | — | — | EP | disclosed |
| CN-101563320-B | [2- (6-fluoro-1H-indol-3-ylsulfanyl) benzyl ] methylamine for the treatment of affective disorders | LUNDBECK & CO AS H | 2012-05-30 | — | — | CN | disclosed |
| US-8138220-B2 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders | H. LUNDBECK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-20110039890-A1 | 4-[2,3-Difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine | H. LUNDBECK A/S (DK) | 2011-02-17 | — | — | US | disclosed |
| CN-101970408-A | 4- [2, 3-difluoro-6- (2-fluoro-4-methyl-phenylsulfanyl) -phenyl ] -piperidine | LUNDBECK & CO AS H | 2011-02-09 | — | — | CN | disclosed |
| EP-2231599-A1 | 4-[2,3-DIFLUORO-6-(2-FLUORO-4-METHYL-PHENYLSULFANYL)-PHENYL]-PIPERIDINE | H. Lundbeck A/S (DK) | 2010-09-29 | — | — | EP | disclosed |
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| CN-101563320-A | [ 2- (6-fluoro-1H-indol-3-ylsulfanyl) benzyl ] methylamine for the treatment of affective disorders | LUNDBECK & CO AS H (DK) | 2009-10-21 | — | — | CN | disclosed |
| EP-2074091-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. Lundbeck A/S (DK) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009076961-A1 | 4-[2,3-DIFLUORO-6-(2-FLUORO-4-METHYL-PHENYLSULFANYL)-PHENYL]-PIPERIDINE | H. LUNDBECK A/S (DK) | 2009-06-25 | — | — | WO | disclosed |
| WO-2008037258-A1 | [2-(6-FLOURO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | H. LUNDBECK A/S (DK) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326036-A1 | [2-(6-FLUORO-1H-INDOL-3-YLSULFANYL)BENZYL]METHYL AMINE FOR THE TREATMENT OF AFFECTIVE DISORDERS | HTR2C, HTR3B, HTR3C | GABRA1 630/4885TSHR 851/4885GABRG2 945/4885 |
| US-20110039890-A1 | 4-[2,3-Difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine | HTR2B, SNCA, HTR1B | GABRA1 311/4885TSHR 421/4885GABRG2 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.