Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11282060 | 0.89 | SPHK1 (0.45) | SPHK1HTR2CHTR2BKCNH2HRH3 | |
| SCHEMBL11285374 | 0.86 | SPHK1 (0.46) | SPHK1PTGES2KMT2A | |
| Cyanide SCHEMBL28768758 | 0.84 | SPHK1 (0.44) | TDP1SPHK1 | |
| SCHEMBL4163040 | 0.83 | HAO1 (0.42) | TDP1HTR2CHTR2BHAO1LMNA | |
| SCHEMBL11676578 | 0.80 | CA2 (0.45) | TDP1SPHK1HTR2CHTR2BHAO1 | |
| SCHEMBL8933997 | 0.80 | SIGMAR1 (0.49) | HAO1PTGES2KMT2A | |
| SCHEMBL11674681 | 0.80 | SPHK1 (0.40) | TDP1SPHK1HTR2CHTR2BHAO1 | |
| SCHEMBL4825135 | 0.80 | SPHK1 (0.51) | SPHK1 | |
| SCHEMBL4363948 | 0.80 | BACE1 (0.56) | TDP1SPHK1PTGES2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5544467 | 0.80 | SPHK1 (0.40) | TDP1SPHK1HTR2CHTR2BHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1153765-C | 4-aryl-1-phenylalkyl-1, 2,3, 6-tetrahydropyridines having neurotrophic and protective activity | ��ŵ�Ѻϳ�ʵ���� | 2004-06-16 | — | — | CN | disclosed |
| EP-0837848-B1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI SYNTHELABO (FR) | 2002-09-11 | — | — | EP | disclosed |
| EP-1216996-A2 | Method to synthesise biphenylyl derivatives | SANOFI-SYNTHELABO (FR) | 2002-06-26 | — | — | EP | disclosed |
| US-5981754-A | TREATMENT OF ANOXIA, ALZHEIMER'S DISEASE, SENILE DEMENTIA, SUBCORTICAL DEMENTIA SUCH AS HUNTINGTON'S CHOREA AND PARKINSON'S DISEASE, DEMENTIA CAUSED BY AIDS, NEUROPATHY | SANOFI (FR) | 1999-11-09 | — | — | US | disclosed |
| CN-1189154-A | 4-aryl-1-phenylalkyl-1,2,3,6-Tetrahydropyridines having neurotrophic and neuroprotective activity | SANOFI SA (FR) | 1998-07-29 | — | — | CN | disclosed |
| EP-0837848-A1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI (FR) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997001536-A1 | 4-ARYL-1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES HAVING NEUROTROPHIC AND NEUROPROTECTIVE ACTIVITY | SANOFI (FR) | 1997-01-16 | — | — | WO | disclosed |