Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 3/20 | 0.34 |
| ▸ | PTGES | O14684 | 7/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398168 | 0.89 | HTRA1 (0.36) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL7402200 | 0.83 | ELANE (0.42) | HTRA1 | |
| SCHEMBL7399095 | 0.77 | ELANE (0.42) | HTRA1 | |
| SCHEMBL8994479 | 0.75 | ELANE (0.49) | — | |
| SCHEMBL7402411 | 0.74 | HTRA1 (0.50) | HTRA1 | |
| SCHEMBL7398314 | 0.70 | HTRA1 (0.37) | MEN1ALDH1A1GLAKMT2AHTRA1 | |
| SCHEMBL9298830 | 0.68 | ELANE (0.51) | — | |
| SCHEMBL7548502 | 0.66 | ELANE (0.71) | — | |
| SCHEMBL7552480 | 0.66 | ELANE (0.64) | — | |
| SCHEMBL7398791 | 0.64 | CTRC (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636142-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021209-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |