Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161873 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL6456940 | 0.88 | — | — | |
| SCHEMBL10435646 | 0.62 | — | — | |
| Bicarbonate SCHEMBL10603331 | 0.61 | — | — | |
| Bicarbonate SCHEMBL28617862 | 0.57 | CRBN (0.77) | — | |
| Succinimide SCHEMBL938030 | 0.57 | CRBN (0.65) | — | |
| Bicarbonate SCHEMBL28617859 | 0.57 | CRBN (0.77) | — | |
| Bicarbonate SCHEMBL9295708 | 0.51 | CA1 (0.46) | — | |
| Bicarbonate SCHEMBL10505866 | 0.51 | TRIM24 (0.41) | SMN1; SMN2 | |
| Succinimide SCHEMBL27849600 | 0.51 | CRBN (0.79) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641779-A1 | Novel 1-amidinopiperdines and 4-amidinomorpholines as aggregation inhibitions | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |