Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397878 | 0.83 | ADRA1A (0.43) | KMT2AADRA1APLATHCRTR1HCRTR2 | |
| SCHEMBL7398211 | 0.82 | OPRM1 (0.50) | KMT2A | |
| Hydrochloric Acid SCHEMBL7398822 | 0.82 | ADRA1A (0.42) | KMT2AADRA1APLATHCRTR1HCRTR2 | |
| SCHEMBL4388788 | 0.76 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL7435681 | 0.75 | KDM1A (0.40) | — | |
| Hydrochloric Acid SCHEMBL1922778 | 0.75 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9821859 | 0.73 | HCRTR1 (0.40) | KMT2AHCRTR1HCRTR2 | |
| SCHEMBL7401290 | 0.73 | HCRTR1 (0.40) | KMT2AHCRTR1HCRTR2 | |
| SCHEMBL7399277 | 0.69 | KMT2A (0.39) | KMT2AADRA1AHCRTR1HCRTR2NMT1 | |
| SCHEMBL1257626 | 0.69 | TSHR (0.60) | KMT2AHCRTR1HCRTR2PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972773-A1 | 2-Oxadiazolyl- or 2-thiadiazolyl-phenylcarbamate and -phenylurea derivatives, their preparation and their use as intermediates | GLAXO GROUP LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| EP-0640081-B1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT4 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2000-01-12 | — | — | EP | disclosed |
| US-5618827-A | TREATING GASTROINTESTINAL, URINARY, CARDIOVASCULAR, CENTRAL NERVOUS SYTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-04-08 | — | — | US | disclosed |
| EP-0640081-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993020071-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |