SCHEMBL7394696

SCHEMBL7394696

Oc1ccc(-c2nc3ccc(Cl)cc3[nH]2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.71
ALDH1A1 P00352 4/20 0.71
HPGD P15428 4/20 0.71
KMT2A Q03164 4/20 0.71
KDM4E B2RXH2 3/20 0.71
TP53 P04637 3/20 0.71
HSD17B10 Q99714 3/20 0.71
MAPT P10636 3/20 0.71
CYP3A4 P08684 1/20 0.71
MAPK1 P28482 1/20 0.71
FTO Q9C0B1 1/20 0.71
NPC1 O15118 3/20 0.64
RAB9A P51151 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
APP P05067 1/20 0.63
GAA P10253 1/20 0.63
NFKB1 P19838 1/20 0.63
SNCA P37840 1/20 0.63
NFKB2 Q00653 1/20 0.63
RELA Q04206 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8396715 0.90 ALDH1A1 (0.81) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL7394693 0.87 KDM4E (0.54) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL7248166 0.86 CHEK1 (0.69) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL21018195 0.84 CHEK1 (0.81) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL4185889 0.84 KDM4E (0.94) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL27202473 0.84 ALDH1A1 (0.82) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL8337597 0.83 KDM4E (1.00) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL29898236 0.83 KDM4E (1.00) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL7396446 0.83 MEN1 (0.70) MEN1ALDH1A1HPGDKMT2AKDM4E
SCHEMBL7164766 0.82 KDM4E (0.73) MEN1ALDH1A1HPGDKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3626699-B1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2023-07-12 EP disclosed
US-20210198220-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-07-01 US disclosed
US-11001563-B2 SSAO inhibitor SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-05-11 US disclosed
US-20200115352-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO., LTD. 2020-04-16 US disclosed
EP-3626699-A1 SSAO INHIBITOR Shandong Danhong Pharmaceutical Co., Ltd. (CN) 2020-03-25 EP disclosed
WO-2001066526-A1 ESTER DERIVATIVES OF DIMETHYLPROPIONIC ACID AND PHARMACETUICAL COMPOSITIONS CONTAINING THEM CERMOL S.A. (CH) 2001-09-13 WO disclosed
EP-1132381-A1 Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them CERMOL S.A. (CH) 2001-09-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001563-B2 SSAO inhibitor SSB, ASAH2, AOX1 MEN1 2857/4885ALDH1A1 177/4885HPGD 601/4885
US-20210198220-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 MEN1 2857/4885ALDH1A1 177/4885HPGD 601/4885
US-20200115352-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 MEN1 2857/4885ALDH1A1 177/4885HPGD 601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.