SCHEMBL8337597

SCHEMBL8337597

Clc1ccc2nc(-c3ccccc3)[nH]c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
ALDH1A1 P00352 5/20 1.00
HPGD P15428 5/20 1.00
MAPT P10636 4/20 1.00
TP53 P04637 4/20 1.00
HSD17B10 Q99714 4/20 1.00
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
CYP3A4 P08684 1/20 1.00
MAPK1 P28482 1/20 1.00
FTO Q9C0B1 1/20 1.00
NPC1 O15118 6/20 0.66
RAB9A P51151 5/20 0.66
SMN1; SMN2 Q16637 4/20 0.66
GAA P10253 3/20 0.66
GLA P06280 1/20 0.66
HTT P42858 1/20 0.66
GFER P55789 1/20 0.66
RCE1 Q9Y256 1/20 0.66
METAP2 P50579 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29898236 1.00 KDM4E (1.00) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL4185889 0.97 KDM4E (0.94) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL8396715 0.89 ALDH1A1 (0.81) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL4188962 0.87 MEN1 (0.76) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL3335842 0.86 KDM4E (0.76) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL7164766 0.85 KDM4E (0.73) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL13299660 0.84 NPC1 (0.72) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL29546367 0.84 HPGD (0.71) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL7394696 0.83 MEN1 (0.71) KDM4EALDH1A1HPGDMAPTTP53
SCHEMBL22955330 0.83 KDM4E (0.71) KDM4EALDH1A1HPGDMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1891393-A Preflux composition BAIK YANG CHEMICAL CO LTD (KR) 2007-01-10 CN claimed
CN-116924995-A Method for synthesizing benzimidazole compound by catalyzing L-phenylalanine 宁夏师范学院 2023-10-24 CN disclosed
CN-114989094-B Method for synthesizing benzimidazole derivative by visible light catalysis 云南民族大学 2023-09-29 CN disclosed
CN-114989094-A Method for synthesizing benzimidazole derivative by visible light catalysis 云南民族大学 2022-09-02 CN disclosed
CN-106802536-B Transfer material, method for producing same, laminate, and method for producing same 富士胶片株式会社 2022-03-04 CN disclosed
US-20220047554-A1 COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS UNIVERSITY OF VIRGINIA 2022-02-17 US disclosed
US-11090289-B2 Compositions and methods for blocking sodium channels UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2021-08-17 US disclosed
US-11090289-B2 Compositions and methods for blocking sodium channels UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2021-08-17 US disclosed
CN-108043442-B Carbon-supported ruthenium nano material, preparation method thereof and application of carbon-supported ruthenium nano material in catalyzing reaction of alcohol and aromatic diamine 苏州大学 2021-03-19 CN disclosed
CN-110716668-A Transfer film, laminate, method for producing same, and use thereof 富士胶片株式会社 2020-01-21 CN disclosed
US-10192651-B2 Transfer material, method of manufacturing transfer material, laminated body, method of manufacturing laminated body, method of manufacturing capacitance-type input device, and method of manufacturing image display device FUJIFILM CORPORATION (JP) 2019-01-29 US disclosed
US-10157695-B2 2018-12-18 US disclosed
US-10059087-B2 Transfer film, method for manufacturing transfer film, laminate, method for manufacturing laminate, capacitive input device, and image display device FUJIFILM CORPORATION (JP) 2018-08-28 US disclosed
WO-2018140504-A1 COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS PATEL MANOJ K (US) 2018-08-02 WO disclosed
CN-106802536-A Transfer materials and its manufacture method, layered product and its manufacture method 富士胶片株式会社 2017-06-06 CN disclosed
US-20170154704-A1 TRANSFER MATERIAL, METHOD OF MANUFACTURING TRANSFER MATERIAL, LAMINATED BODY, METHOD OF MANUFACTURING LAMINATED BODY, METHOD OF MANUFACTURING CAPACITANCE-TYPE INPUT DEVICE, AND METHOD OF MANUFACTURING IMAGE DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2017-06-01 US disclosed
CN-106660309-A Transfer film, method for manufacturing transfer film, laminate, method for manufacturing laminate, capacitance-type input device, and image display device 富士胶片株式会社 2017-05-10 CN disclosed
US-20170095999-A1 TRANSFER FILM, METHOD FOR MANUFACTURING TRANSFER FILM, LAMINATE, METHOD FOR MANUFACTURING LAMINATE, CAPACITIVE INPUT DEVICE, AND IMAGE DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2017-04-06 US disclosed
CN-1891393-A Preflux composition BAIK YANG CHEMICAL CO LTD (KR) 2007-01-10 CN disclosed
WO-2004041209-A2 TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF PARATEK PHARMACEUTICALS, INC. (US) 2004-05-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11090289-B2 Compositions and methods for blocking sodium channels SCN3A, SCN1B, SCN2B KDM4E 4354/4885ALDH1A1 2497/4885HPGD 1152/4885
US-20220047554-A1 COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS SCN3A, SCN1B, SCN2B KDM4E 4354/4885ALDH1A1 2497/4885HPGD 1152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.