Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9862074 | 0.72 | NPC1 (0.55) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL8579371 | 0.69 | POLB (0.44) | POLBL3MBTL1LIPEKCNA5 | |
| SCHEMBL24997232 | 0.68 | POLB (0.59) | POLBL3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL21383412 | 0.68 | L3MBTL1 (0.54) | POLBL3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL1257933 | 0.68 | POLB (0.43) | POLBL3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL14638126 | 0.68 | KCNA5 (0.42) | POLBL3MBTL1GABRA1GABRG2GABRB3 | |
| SCHEMBL29471932 | 0.67 | KCNA5 (0.50) | POLBL3MBTL1MAPTEPHX2ALDH1A1 | |
| SCHEMBL2426703 | 0.67 | KCNA5 (0.50) | POLBL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL6177616 | 0.67 | LIPE (0.46) | POLBL3MBTL1PIM1PIM2LIPE | |
| SCHEMBL15576793 | 0.67 | LIPE (0.51) | POLBL3MBTL1NPBWR1MCHR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001092257-A1 | OXO-IMIDAZOPYRIMIDINE-CARBOXAMIDES AND THEIR USE AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2001-12-06 | — | — | WO | claimed |