Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394539 | 0.92 | KMT2A (0.50) | NPC1RAB9AHTTSMN1; SMN2KMT2A | |
| SCHEMBL7388689 | 0.91 | ENPP1 (0.51) | NPC1RAB9AHTTSMN1; SMN2KMT2A | |
| SCHEMBL7394697 | 0.90 | PRMT1 (0.45) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL7396365 | 0.83 | NPC1 (0.51) | NPC1RAB9AKMT2APOLBPPARG | |
| SCHEMBL7394619 | 0.82 | PRMT1 (0.52) | NPC1SMN1; SMN2KMT2APOLBPPARG | |
| SCHEMBL7398968 | 0.82 | PRMT1 (0.52) | NPC1SMN1; SMN2KMT2APOLBPPARG | |
| SCHEMBL7396547 | 0.80 | TRPV1 (0.48) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7395666 | 0.80 | NAMPT (0.49) | RAB9AHTTSMN1; SMN2KMT2APOLB | |
| SCHEMBL7493288 | 0.80 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7397210 | 0.76 | MEN1 (0.56) | NPC1RAB9ASMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002006215-A1 | 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-24 | — | — | WO | claimed |
| WO-2002006215-A1 | 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-24 | — | — | WO | disclosed |