Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.38 |
| ▸ | OPRD1 known ✓ | P41143 | 4/20 | 0.38 |
| ▸ | OPRK1 known ✓ | P41145 | 4/20 | 0.38 |
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.36 |
| ▸ | HRH2 | P25021 | 8/20 | 0.38 |
| ▸ | DRD2 | P14416 | 8/20 | 0.38 |
| ▸ | DRD3 | P35462 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7396155 | 0.85 | DRD2 (0.41) | DRD2DRD3OPRM1OPRD1OPRK1 | |
| Cadaverine Tartrate SCHEMBL7327577 | 0.84 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2 | |
| Fumaric Acid SCHEMBL9872705 | 0.75 | HRH2 (0.49) | HRH2DRD2DRD3HRH4HRH1 | |
| Fumaric Acid SCHEMBL7270229 | 0.75 | HRH2 (0.49) | HRH2DRD2DRD3HRH4HRH1 | |
| Hydrochloric Acid SCHEMBL7298682 | 0.74 | HRH2 (0.47) | HRH2DRD2DRD3OPRM1OPRD1 | |
| Fumaric Acid SCHEMBL9871662 | 0.74 | HRH2 (0.48) | HRH2DRD2DRD3OPRM1OPRD1 | |
| Fumaric Acid SCHEMBL7269782 | 0.74 | HRH2 (0.48) | HRH2DRD2DRD3OPRM1OPRD1 | |
| Cadaverine Tartrate SCHEMBL9872238 | 0.69 | ALDH1A1 (0.45) | — | |
| Hydrochloric Acid SCHEMBL7268936 | 0.67 | ALDH1A1 (0.54) | DRD2DRD3OPRM1OPRD1OPRK1 | |
| SCHEMBL8589943 | 0.67 | DRD2 (0.56) | DRD2DRD3OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5418235-A | Hypotensive, Parkinson's disease, schizophrenia | BASF AKTIENGESELLSCHAFT (DE) | 1995-05-23 | — | — | US | claimed |
| EP-0589903-B1 | AMINOALKYL-SUBSTITUTED 5-MERCAPTOTHIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AG (DE) | 1998-09-09 | — | — | EP | disclosed |
| US-5418235-A | Hypotensive, Parkinson's disease, schizophrenia | BASF AKTIENGESELLSCHAFT (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0589903-A1 | AMINOALKYL-SUBSTITUTED 5-MERCAPTOTHIAZOLES, THEIR PREPARATION AND THEIR USE | BASF Aktiengesellschaft (DE) | 1994-04-06 | — | — | EP | disclosed |
| WO-1992022540-A1 | AMINOALKYL-SUBSTITUTED 5-MERCAPTOTHIAZOLES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1992-12-23 | — | — | WO | disclosed |