Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | ADAMTS1 | Q9UHI8 | 3/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.39 |
| ▸ | MMP7 | P09237 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598698 | 0.85 | ADAM17 (0.57) | ADAM17ADAMTS4MMP3ADAMTS1ADAMTS5 | |
| SCHEMBL7396293 | 0.84 | ADAM17 (0.48) | SMN1; SMN2ADAM17ADAMTS4MMP3ADAMTS1 | |
| SCHEMBL7403617 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2ADAM17ADAMTS4MMP3ADAMTS1 | |
| Trifluoroacetic Acid SCHEMBL6596919 | 0.82 | ADAM17 (0.53) | ADAM17ADAMTS4MMP3ADAMTS1ADAMTS5 | |
| SCHEMBL7400907 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2ADAM17ADAMTS4MMP3ADAMTS1 | |
| SCHEMBL6596246 | 0.77 | ADAM17 (0.61) | ADAM17ADAMTS4MMP3ADAMTS1ADAMTS5 | |
| SCHEMBL7407612 | 0.76 | ADAM17 (0.51) | SMN1; SMN2ADAM17ADAMTS4MMP3ADAMTS1 | |
| SCHEMBL6595798 | 0.74 | ADAM17 (0.57) | ADAM17ADAMTS4MMP3ADAMTS1ADAMTS5 | |
| SCHEMBL7402599 | 0.74 | ADAM17 (0.55) | SMN1; SMN2ADAM17MMP3MAPTMEN1 | |
| SCHEMBL7404237 | 0.74 | ADAM17 (0.47) | SMN1; SMN2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |