Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407963 | 0.84 | ADAM17 (0.48) | ADAM17SMN1; SMN2ADAM10MMP1 | |
| SCHEMBL7404740 | 0.81 | SMN1; SMN2 (0.50) | ADAM17SMN1; SMN2ADAM10MMP1 | |
| SCHEMBL7400898 | 0.77 | ADAM17 (0.67) | ADAM17 | |
| SCHEMBL7403617 | 0.76 | SMN1; SMN2 (0.44) | ADAM17SMN1; SMN2 | |
| SCHEMBL6629887 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2 | |
| SCHEMBL7400907 | 0.75 | SMN1; SMN2 (0.53) | ADAM17SMN1; SMN2ADAM10MMP1 | |
| SCHEMBL7402599 | 0.75 | ADAM17 (0.55) | ADAM17SMN1; SMN2ADAM10MMP1 | |
| SCHEMBL7401098 | 0.74 | ADAM17 (0.61) | ADAM17 | |
| SCHEMBL7399912 | 0.74 | ADAM17 (0.73) | ADAM17 | |
| SCHEMBL6633286 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |