Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 14/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 14/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 14/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 14/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 14/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396408 | 0.73 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL5784045 | 0.72 | PTPN1 (0.82) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31337366 | 0.68 | LMNA (0.72) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31337279 | 0.68 | MAPT (0.52) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL23091217 | 0.67 | PTPN1 (0.76) | PTPN1PTPN11LMNAMAPTMAPK1 | |
| SCHEMBL5784054 | 0.67 | PTPN1 (0.68) | PTPN1PTPN11LMNAMAPTMAPK1 | |
| SCHEMBL23091206 | 0.66 | PTPN1 (0.66) | PTPN1PTPN11LMNAMAPTMAPK1 | |
| SCHEMBL4688548 | 0.65 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31337212 | 0.65 | PTPN1 (0.64) | PTPN1PTPN11LMNAMAPTMAPK1 | |
| SCHEMBL28958728 | 0.65 | RAB9A (0.63) | PTPN1PTPN11LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599937-A | Heteroaromatic quinuclidinenes, their use and preparation | PHARMACIA AB (SE) | 1997-02-04 | — | — | US | disclosed |
| EP-0640082-A1 | HETEROAROMATIC QUINUCLIDINENES, THEIR USE AND PREPARATION | Pharmacia & Upjohn Aktiebolag (SE) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023395-A1 | HETEROAROMATIC QUINUCLIDINENES, THEIR USE AND PREPARATION | KABI PHARMACIA AB (SE) | 1993-11-25 | — | — | WO | disclosed |