Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.65 |
| ▸ | PLAU | P00749 | 3/20 | 0.65 |
| ▸ | PLAT | P00750 | 3/20 | 0.65 |
| ▸ | PLG | P00747 | 2/20 | 0.60 |
| ▸ | KLK8 | O60259 | 1/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | KLK2 | P20151 | 1/20 | 0.59 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.59 |
| ▸ | KYNU | Q16719 | 1/20 | 0.59 |
| ▸ | ECE1 | P42892 | 7/20 | 0.57 |
| ▸ | MME | P08473 | 7/20 | 0.57 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.57 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197778 | 0.90 | F2 (0.58) | F2PLAUPLATPLGKLK8 | |
| SCHEMBL7397375 | 0.88 | ECE1 (0.59) | F2PLAUPLATKYNUECE1 | |
| SCHEMBL14376753 | 0.87 | F2 (0.63) | F2PLAUPLATPLGKLK8 | |
| SCHEMBL7403534 | 0.85 | F2 (0.86) | F2PLAUPLATPLGKLK8 | |
| SCHEMBL7291199 | 0.85 | ECE1 (0.61) | F2PLAUPLATECE1MME | |
| SCHEMBL14334539 | 0.85 | ECE1 (0.63) | F2PLAUPLATPLGECE1 | |
| SCHEMBL7328702 | 0.85 | ECE1 (0.63) | F2PLAUPLATPLGECE1 | |
| SCHEMBL12942520 | 0.83 | ELANE (0.61) | KYNUACE2CTRB1ELANE | |
| SCHEMBL187849 | 0.83 | KYNU (0.62) | F2PLAUPLATKYNUCTRB1 | |
| SCHEMBL269404 | 0.83 | KYNU (0.62) | F2PLAUPLATKYNUCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504070-A | ADMINISTERING OLIGOPEPTIDES, PHOSPHONATES AND MODIFIED AMINO ACIDS AS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1996-04-02 | — | — | US | disclosed |
| WO-1993011154-A1 | INHIBITORS OF THE CONVERSION OF BIG ENDOTHELIN TO ENDOTHELIN | BERLEX LABORATORIES, INC. (US) | 1993-06-10 | — | — | WO | disclosed |
| US-4379146-A | Substituted phosphonamides as antihypertensives | MERCK & CO., INC. (US) | 1983-04-05 | — | — | US | disclosed |
| EP-0058427-A2 | Substituted phosphonamides, a process for preparing the same and a pharmaceutical composition which is useful in the treatment of hypertension | MERCK & CO. INC. (US) | 1982-08-25 | — | — | EP | disclosed |