Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3355262 | 0.74 | TSHR (0.35) | TSHRALDH1A1HPGDZDHHC20ZDHHC2 | |
| SCHEMBL9464579 | 0.73 | TSHR (0.42) | TSHRALDH1A1HPGDZDHHC20ZDHHC2 | |
| SCHEMBL437089 | 0.67 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL203812 | 0.67 | TSHR (0.33) | TSHRALDH1A1 | |
| SCHEMBL16671361 | 0.65 | — | — | |
| SCHEMBL16667046 | 0.65 | — | — | |
| SCHEMBL4782406 | 0.65 | — | — | |
| SCHEMBL4782408 | 0.65 | — | — | |
| SCHEMBL1028079 | 0.64 | TSHR (0.38) | TSHRALDH1A1 | |
| SCHEMBL1899483 | 0.64 | ALDH1A1 (0.30) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734385-B1 | SUBSTITUTED 2-CARBOXYALKYL-3-(FLUOROPHENYL)-8-(3-HALOPROPEN-2-YL) NORTROPANES AND THEIR USE AS IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | GEN HOSPITAL CORP (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1081147-A2 | Substituted nortropanes and their use as imaging agents for neurodegenerative disorders | THE GENERAL HOSPITAL CORPORATION (US) | 2001-03-07 | — | — | EP | disclosed |
| US-5853696-A | Substituted 2-carboxyalkyl-3(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging agents for neurodegenerative disorders | ORGANIX, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0734385-A4 | SUBSTITUTED 2-CARBOXYALKYL-3-(FLUOROPHENYL)-8-(3-HALOPROPEN-2-YL) NORTROPANES AND THEIR USE AS IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | GEN HOSPITAL CORP (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0734385-A1 | SUBSTITUTED 2-CARBOXYALKYL-3-(FLUOROPHENYL)-8-(3-HALOPROPEN-2-YL) NORTROPANES AND THEIR USE AS IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5493026-A | LABELED WITH RADIOACTIVE ISOTOPES FOR TOMOGRAPHY | ORGANIX, INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1995011901-A9 | SUBSTITUTED 2-CARBOXYALKYL-3-(FLUOROPHENYL)-8-(3-HALOPROPEN-2-YL) NORTROPANES AND THEIR USE AS IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | — | 1995-06-15 | — | — | WO | disclosed |
| WO-1995011901-A1 | SUBSTITUTED 2-CARBOXYALKYL-3-(FLUOROPHENYL)-8-(3-HALOPROPEN-2-YL) NORTROPANES AND THEIR USE AS IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 1995-05-04 | — | — | WO | disclosed |